Staphylococcus aureus bacteremia is serious medical problem in association with high morbidity and mortality. I analysed 105 patients with Saureus becteremia who were admitted to the Inje University Pusan Paik Hospital from Jan. 1990 to Dec.
1993,
retrospectively.
@ES The following results were obtained
@EN 1) 69%(72/105) of all were nosocomial infections and 31%(33/105) were community-acquired infection. Incidence of MRSA and MSSA bacteremia among all cases were 48%(50/105) and 52%(55/105), respectively. In nosocomial infection, incidence of
MRSA
bacteremia(60%) was significantly higher than that of MSSA bacteremia(21%), and incidence of MRSA bacteremia was significantly higher in surgical patients than in medical patients.
2) The main foci of infections were skin wounds(28%), IV catheters(15%) and the respiratory tract(8%), but the foci was unknown in nearly half of all cases.
3) Common underlying diseases were renal failure, malignancy, perinatal diseases, traumatic diseases, DM and cardiovascular diseases.
4) The majority of patients had fever and leukocytosis (100% and 90%). Hypotension and thrombocytopenia were observed in 72% and 26% of all cases, respectively.
5) The risk factors associated with MRSA bacteremia were various invasive procedures including central IV cathter and nosocomial infection, especially skin wound infections in surgical patients.
6) The case fatality rate for patients with S.aureus barteremia was 35%, and that for MRSA bacteremia(42%) was higher than that for MSSA bacteremia(29%), but there was no significant difference between the two groups. The case fatality rate for
nosocomial and community-acquired S.aureus bacteremia were also similar in this study.
In conclusion. S.aureus bacteremia (esp. MRSA bacteremia) resulted in considerable morbidity and mortality in our patient population. Especically, MRSA bacteremias were associated with varous invasive procedures including central IV catheter and
nosocomial skin wound infection in surgical patients. Therefore, hospital personnel should make an effort to minimize S.aureus infection and reduce death due to S.aureus bacteremia through careful aspectic measures and handling of skin wounds and
various invasive procedures including central IV catheter.
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